Ara
Toplam kayıt 11, listelenen: 1-10
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
(Taylor & Francis Ltd, 2021)
Aims The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ...
Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation
(Wiley-V C H Verlag Gmbh, 2019)
Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) ...
The Utilization of Poly(2-ethyl-2-oxazoline)-b-Poly(epsilon-caprolactone) Ellipsoidal Particles for Intracellular BIKDDA Delivery to Prostate Cancer
(Wiley-V C H Verlag Gmbh, 2021)
Prostate cancer is the most common cancer, which is about 15-20% among male cancers worldwide. As most common strategies such as radiotherapy, chemotherapy, or surgery alone can be unsuccessful in the treatment of prostate ...
Development of novel self-assembled polymeric micelles from partially hydrolysed poly(2-ethyl-2-oxazoline)-co-PEI-b-PCL block copolymer as non-viral vectors for plasmid DNA in vitro transfection
(Taylor & Francis Ltd, 2018)
A new efficient, non-viral gene delivery cationic polymeric micellar system was developed by partial hydrolysis of poly(2-ethyl-2-oxazoline) (PEtOx) with two different hydrolysis percentages of PEtOx (30% and 60%) to reduce ...
A robust optimization approach for the breast cancer targeted design of PEtOx-b-PLA polymersomes
(Elsevier, 2021)
The equipping of nanoparticles with the peptide moiety recognizing a particular receptor, enables cell or tissue specific targeting, therefore the optimization of the targeted nanoparticles is a key factor in the formulation ...
Development of self-assembled poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone) (PEtOx-b-PCL) copolymeric nanostructures in aqueous solution and evaluation of their morphological transitions
(Budapest Univ Technol & Econ, 2020)
Amphiphilic block copolymers are known to self-assemble into various morphologies, including ellipsoids, tubular structures, toroids, vesicles, micellar structures. In this paper, we discuss the synthesis of copolymeric ...
Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles
(Taylor & Francis Ltd, 2020)
Aims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block ...
The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions
(Wiley, 2021)
To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these ...
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
(Taylor and Francis, 2021)
Aims: The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ...
Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer
(Elsevier, 2021)
Breast cancer, a heterogeneous disease, has the highest incidence rate and is a major cause of death in females worldwide. Drug delivery by using nanotechnology has shown great promise for improving cancer treatment. ...