Yazar "Özköse, Umut Uğur" için listeleme
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Delivery of doxorubicin loaded P18 conjugated-poly (2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer
Bolat, Zeynep Busra; Nezir, Ayca Ece; Devrim, Burcu; Zemheri, Ebru; Gulyuz, Sevgi; Ozkose, Umut Ugur; Bozkir, Asuman; Telci, Dilek; Sahin, Fikrettin (Elsevier, 2021)Breast cancer, a heterogeneous disease, has the highest incidence rate and is a major cause of death in females worldwide. Drug delivery by using nanotechnology has shown great promise for improving cancer treatment. ... -
Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer
Bolat, Zeynep Büşra; Nezir, Ayça Ece; Devrim, Burcu; Zemheri, Ebru; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman; Telci, Dilek; Şahin, Fikrettin (Elsevier, 2021)Breast cancer, a heterogeneous disease, has the highest incidence rate and is a major cause of death in females worldwide. Drug delivery by using nanotechnology has shown great promise for improving cancer treatment. ... -
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
Devrim, Burcu; Bolat, Zeynep Büşra; Telci, Dilek; Şahin, Fikrettin; Gülyüz, Sevgi; Özköse, Umut Uğur (Taylor & Francis Ltd, 2021)Aims The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ... -
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
Devrim, Burcu; Bolat, Zeynep Büşra; Telci, Dilek; Şahin, Fikrettin; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman (Taylor and Francis, 2021)Aims: The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ... -
Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation
Öz, Umut Can; Küçüktürkmen, Berrin; Özköse, Umut Uğur; Gülyüz, Sevgi; Bolat, Zeynep Büşra; Telci, Dilek (Wiley-V C H Verlag Gmbh, 2019)Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) ... -
Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
Küçüktürkmen, Berrin; Öz, Umut Can; Er, Engin; Gómez, I. Jénnifer; Tekneci, Seda İpek; Eşim, Özgür; Özköse, Umut Uğur; Gülyüz, Sevgi; Üstündağ, Aylin; Yılmaz, Özgür; Zajíčková, Lenka; Bozkır, Asuman (John Wiley and Sons Inc., 2024)In recent years, multifunctional nanocarriers that provide simultaneous drug delivery and imaging have attracted enormous attention, especially in cancer treatment. In this research, a biocompatible fluorescent multifunctional ... -
Development of novel self-assembled polymeric micelles from partially hydrolysed poly(2-ethyl-2-oxazoline)-co-PEI-b-PCL block copolymer as non-viral vectors for plasmid DNA in vitro transfection
Kara, Aslı; Öztürk, Naile; Esendağlı, Güneş; Özköse, Umut Uğur; Gülyüz, Sevgi; Yılmaz, Özgür (Taylor & Francis Ltd, 2018)A new efficient, non-viral gene delivery cationic polymeric micellar system was developed by partial hydrolysis of poly(2-ethyl-2-oxazoline) (PEtOx) with two different hydrolysis percentages of PEtOx (30% and 60%) to reduce ... -
Development of self-assembled poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone) (PEtOx-b-PCL) copolymeric nanostructures in aqueous solution and evaluation of their morphological transitions
Özköse, Umut Uğur; Gülyüz, Sevgi; Öz, Umut Can; Taşdelen, Mehmet Atilla; Alptürk, Onur; Bozkır, Asuman (Budapest Univ Technol & Econ, 2020)Amphiphilic block copolymers are known to self-assemble into various morphologies, including ellipsoids, tubular structures, toroids, vesicles, micellar structures. In this paper, we discuss the synthesis of copolymeric ... -
Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles
Öztürk, Naile; Kara, Aslı; Gülyüz, Sevgi; Özköse, Umut Uğur; Taşdelen, Mehmet Atilla; Bozkır, Asuman (Taylor & Francis Ltd, 2020)Aims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block ... -
PEtOx-DOPE nanoliposomes functionalized with peptide 563 in targeted BikDDA delivery to prostate cancer
Nezir, Ayca Ece; Bolat, Zeynep Büşra; Saka, Ongun Mehmet; Zemheri, Itır Ebru; Gülyüz, Sevgi; Özköse, Umut Uğur; Yilmaz, Özgür; Bozkir, Asuman; Şahin, Fikrettin; Telci, Dilek (TUBITAK, 2024)Background: Nanocarrier-based systems have cultivated significant improvements in prostate cancer therapy. However, the efforts are still limited in clinical applicability, and more research is required for the development ... -
Poly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(epsilon-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activity
Gülyüz, Sevgi; Özköse, Umut Uğur; Khalily, Melek Parlak; Kesici, Mehmet Seçkin; Koçak, Polen; Bolat, Zeynep Büşra; Kara, Aslı; Öztürk, Naile; Özçubukçu, Salih; Bozkır, Asuman; Alptürk, Onur; Telci, Dilek; Şahin, Fikrettin; Vural, İmran; Yılmaz, Özgür (Royal Society of Chemistry, 2021)Here we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer specific targeting ... -
Preparation and characterization of electrically conductive multiwalled carbon nanotube/polyoxazoline nanocomposite films using spray coating
Oytun, Faruk; Özköse, Umut Uğur (Springer, 2019)Multiwalled carbon nanotube/poly(2-ethyl-2-oxazoline) (MWCNT/PEtOx) nanocomposites with different MWCNT content were successfully prepared by amidation reaction between amine-terminated PEtOx (PEtOx-NH2) and carboxylic ... -
A robust optimization approach for the breast cancer targeted design of PEtOx-b-PLA polymersomes
Öz, Umut Can; Bolat, Zeynep Büşra; Özköse, Umut Uğur; Gülyüz, Sevgi; Küçüktürkmen, Berrin; Khalily, Melek Parlak (Elsevier, 2021)The equipping of nanoparticles with the peptide moiety recognizing a particular receptor, enables cell or tissue specific targeting, therefore the optimization of the targeted nanoparticles is a key factor in the formulation ... -
The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions
Özköse, Umut Uğur; Gülyüz, Sevgi; Parlak Khalily, Melek; Özçubukçu, Salih; Bozkır, Asuman; Taşdelen, Mehmet Atilla (Wiley, 2021)To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these ... -
Synthesis of poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone) conjugates by a new modular strategy
Özköse, Umut Uğur; Yılmaz, Özgür; Alptürk, Onur (Springer, 2020)Amphiphilic block copolymers where hydrophobicity and hydrophilicity coincide are essential building blocks for many supramolecular systems. By this time, polyethylene glycol (PEG) has been a conventional choice to constitute ... -
Synthesis, biocompatibility and gene encapsulation of poly(2-Ethyl 2-Oxazoline)-dioleoyl phosphatidylethanolamine (PEtOx-DOPE) and post-modifications with peptides and fluorescent dye coumarin
Gülyüz, S.; Bayram, D.; Özköse, Umut Uğur; Bolat, Zeynep Büşra; Kocak, P.; Saka, O.M. (Taylor and Francis Inc., 2020)Liposome surface modifications serve great potential applications of liposomes, for instance, increasing stability, bioactive liposome conjugates, and targeted drug, gene, and image agent delivery. In this study, novel ... -
Targeting prostate cancer with docetaxel-loaded peptide 563-conjugated PEtOx-co-PEI30%-b-PCL polymeric micelle nanocarriers
Nezir, Ayca Ece; Bolat, Zeynep Busra; Ozturk, Naile; Kocak, Polen; Zemheri, Ebru; Gulyuz, Sevgi; Özköse, Umut Uğur; Yilmaz, Ozgur; Vural, Imran; Bozkır, Asuman; Şahin, Fikrettin; Telci, Dilek (Springer, 2023)Prostate cancer is a global disease that negatively affects the quality of life. Although various strategies against prostate cancer have been developed, only a few achieved tumor-specific targeting. Therefore, a special ... -
The Utilization of Poly(2-ethyl-2-oxazoline)-b-Poly(epsilon-caprolactone) Ellipsoidal Particles for Intracellular BIKDDA Delivery to Prostate Cancer
Koçak, Polen; Öz, Umut Can; Bolat, Zeynep Büşra; Özköse, Umut Uğur; Gülyüz, Sevgi; Taşdelen, Mehmet Atilla (Wiley-V C H Verlag Gmbh, 2021)Prostate cancer is the most common cancer, which is about 15-20% among male cancers worldwide. As most common strategies such as radiotherapy, chemotherapy, or surgery alone can be unsuccessful in the treatment of prostate ...
