Yazar "Bolat, Zeynep Büşra" için listeleme
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Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer
Bolat, Zeynep Büşra; Nezir, Ayça Ece; Devrim, Burcu; Zemheri, Ebru; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman; Telci, Dilek; Şahin, Fikrettin (Elsevier, 2021)Breast cancer, a heterogeneous disease, has the highest incidence rate and is a major cause of death in females worldwide. Drug delivery by using nanotechnology has shown great promise for improving cancer treatment. ... -
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
Devrim, Burcu; Bolat, Zeynep Büşra; Telci, Dilek; Şahin, Fikrettin; Gülyüz, Sevgi; Özköse, Umut Uğur (Taylor & Francis Ltd, 2021)Aims The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ... -
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
Devrim, Burcu; Bolat, Zeynep Büşra; Telci, Dilek; Şahin, Fikrettin; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman (Taylor and Francis, 2021)Aims: The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ... -
Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation
Öz, Umut Can; Küçüktürkmen, Berrin; Özköse, Umut Uğur; Gülyüz, Sevgi; Bolat, Zeynep Büşra; Telci, Dilek (Wiley-V C H Verlag Gmbh, 2019)Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) ... -
PEtOx-DOPE nanoliposomes functionalized with peptide 563 in targeted BikDDA delivery to prostate cancer
Nezir, Ayca Ece; Bolat, Zeynep Büşra; Saka, Ongun Mehmet; Zemheri, Itır Ebru; Gülyüz, Sevgi; Özköse, Umut Uğur; Yilmaz, Özgür; Bozkir, Asuman; Şahin, Fikrettin; Telci, Dilek (TUBITAK, 2024)Background: Nanocarrier-based systems have cultivated significant improvements in prostate cancer therapy. However, the efforts are still limited in clinical applicability, and more research is required for the development ... -
Poly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(epsilon-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activity
Gülyüz, Sevgi; Özköse, Umut Uğur; Khalily, Melek Parlak; Kesici, Mehmet Seçkin; Koçak, Polen; Bolat, Zeynep Büşra; Kara, Aslı; Öztürk, Naile; Özçubukçu, Salih; Bozkır, Asuman; Alptürk, Onur; Telci, Dilek; Şahin, Fikrettin; Vural, İmran; Yılmaz, Özgür (Royal Society of Chemistry, 2021)Here we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer specific targeting ... -
A robust optimization approach for the breast cancer targeted design of PEtOx-b-PLA polymersomes
Öz, Umut Can; Bolat, Zeynep Büşra; Özköse, Umut Uğur; Gülyüz, Sevgi; Küçüktürkmen, Berrin; Khalily, Melek Parlak (Elsevier, 2021)The equipping of nanoparticles with the peptide moiety recognizing a particular receptor, enables cell or tissue specific targeting, therefore the optimization of the targeted nanoparticles is a key factor in the formulation ... -
Synthesis, biocompatibility and gene encapsulation of poly(2-Ethyl 2-Oxazoline)-dioleoyl phosphatidylethanolamine (PEtOx-DOPE) and post-modifications with peptides and fluorescent dye coumarin
Gülyüz, S.; Bayram, D.; Özköse, Umut Uğur; Bolat, Zeynep Büşra; Kocak, P.; Saka, O.M. (Taylor and Francis Inc., 2020)Liposome surface modifications serve great potential applications of liposomes, for instance, increasing stability, bioactive liposome conjugates, and targeted drug, gene, and image agent delivery. In this study, novel ... -
The Utilization of Poly(2-ethyl-2-oxazoline)-b-Poly(epsilon-caprolactone) Ellipsoidal Particles for Intracellular BIKDDA Delivery to Prostate Cancer
Koçak, Polen; Öz, Umut Can; Bolat, Zeynep Büşra; Özköse, Umut Uğur; Gülyüz, Sevgi; Taşdelen, Mehmet Atilla (Wiley-V C H Verlag Gmbh, 2021)Prostate cancer is the most common cancer, which is about 15-20% among male cancers worldwide. As most common strategies such as radiotherapy, chemotherapy, or surgery alone can be unsuccessful in the treatment of prostate ...
