Yazar "Bozkır, Asuman" için listeleme
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Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer
Bolat, Zeynep Büşra; Nezir, Ayça Ece; Devrim, Burcu; Zemheri, Ebru; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman; Telci, Dilek; Şahin, Fikrettin (Elsevier, 2021)Breast cancer, a heterogeneous disease, has the highest incidence rate and is a major cause of death in females worldwide. Drug delivery by using nanotechnology has shown great promise for improving cancer treatment. ... -
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
Devrim, Burcu; Bolat, Zeynep Büşra; Telci, Dilek; Şahin, Fikrettin; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman (Taylor and Francis, 2021)Aims: The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ... -
Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
Küçüktürkmen, Berrin; Öz, Umut Can; Er, Engin; Gómez, I. Jénnifer; Tekneci, Seda İpek; Eşim, Özgür; Özköse, Umut Uğur; Gülyüz, Sevgi; Üstündağ, Aylin; Yılmaz, Özgür; Zajíčková, Lenka; Bozkır, Asuman (John Wiley and Sons Inc., 2024)In recent years, multifunctional nanocarriers that provide simultaneous drug delivery and imaging have attracted enormous attention, especially in cancer treatment. In this research, a biocompatible fluorescent multifunctional ... -
Development of self-assembled poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone) (PEtOx-b-PCL) copolymeric nanostructures in aqueous solution and evaluation of their morphological transitions
Özköse, Umut Uğur; Gülyüz, Sevgi; Öz, Umut Can; Taşdelen, Mehmet Atilla; Alptürk, Onur; Bozkır, Asuman (Budapest Univ Technol & Econ, 2020)Amphiphilic block copolymers are known to self-assemble into various morphologies, including ellipsoids, tubular structures, toroids, vesicles, micellar structures. In this paper, we discuss the synthesis of copolymeric ... -
Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles
Öztürk, Naile; Kara, Aslı; Gülyüz, Sevgi; Özköse, Umut Uğur; Taşdelen, Mehmet Atilla; Bozkır, Asuman (Taylor & Francis Ltd, 2020)Aims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block ... -
Poly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(epsilon-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activity
Gülyüz, Sevgi; Özköse, Umut Uğur; Khalily, Melek Parlak; Kesici, Mehmet Seçkin; Koçak, Polen; Bolat, Zeynep Büşra; Kara, Aslı; Öztürk, Naile; Özçubukçu, Salih; Bozkır, Asuman; Alptürk, Onur; Telci, Dilek; Şahin, Fikrettin; Vural, İmran; Yılmaz, Özgür (Royal Society of Chemistry, 2021)Here we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer specific targeting ... -
The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions
Özköse, Umut Uğur; Gülyüz, Sevgi; Parlak Khalily, Melek; Özçubukçu, Salih; Bozkır, Asuman; Taşdelen, Mehmet Atilla (Wiley, 2021)To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these ...
