Yazar "Gülyüz, Sevgi" için listeleme
-
Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer
Bolat, Zeynep Büşra; Nezir, Ayça Ece; Devrim, Burcu; Zemheri, Ebru; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman; Telci, Dilek; Şahin, Fikrettin (Elsevier, 2021)Breast cancer, a heterogeneous disease, has the highest incidence rate and is a major cause of death in females worldwide. Drug delivery by using nanotechnology has shown great promise for improving cancer treatment. ... -
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
Devrim, Burcu; Bolat, Zeynep Büşra; Telci, Dilek; Şahin, Fikrettin; Gülyüz, Sevgi; Özköse, Umut Uğur (Taylor & Francis Ltd, 2021)Aims The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ... -
Design and evaluation of peptide-18-targeted nanoliposomes constructed by poly(2-oxazoline)-DOPE for doxorubicin delivery
Devrim, Burcu; Bolat, Zeynep Büşra; Telci, Dilek; Şahin, Fikrettin; Gülyüz, Sevgi; Özköse, Umut Uğur; Yılmaz, Özgür; Bozkır, Asuman (Taylor and Francis, 2021)Aims: The aim of this study is to develop targeted nanoliposome formulations to provide efficient treatment for breast cancer. In this study, peptide 18-modified poly(2-ethyl-2-oxazoline)-dioleoylphosphatidylethanolamine ... -
Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation
Öz, Umut Can; Küçüktürkmen, Berrin; Özköse, Umut Uğur; Gülyüz, Sevgi; Bolat, Zeynep Büşra; Telci, Dilek (Wiley-V C H Verlag Gmbh, 2019)Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) ... -
Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
Küçüktürkmen, Berrin; Öz, Umut Can; Er, Engin; Gómez, I. Jénnifer; Tekneci, Seda İpek; Eşim, Özgür; Özköse, Umut Uğur; Gülyüz, Sevgi; Üstündağ, Aylin; Yılmaz, Özgür; Zajíčková, Lenka; Bozkır, Asuman (John Wiley and Sons Inc., 2024)In recent years, multifunctional nanocarriers that provide simultaneous drug delivery and imaging have attracted enormous attention, especially in cancer treatment. In this research, a biocompatible fluorescent multifunctional ... -
Development of novel self-assembled polymeric micelles from partially hydrolysed poly(2-ethyl-2-oxazoline)-co-PEI-b-PCL block copolymer as non-viral vectors for plasmid DNA in vitro transfection
Kara, Aslı; Öztürk, Naile; Esendağlı, Güneş; Özköse, Umut Uğur; Gülyüz, Sevgi; Yılmaz, Özgür (Taylor & Francis Ltd, 2018)A new efficient, non-viral gene delivery cationic polymeric micellar system was developed by partial hydrolysis of poly(2-ethyl-2-oxazoline) (PEtOx) with two different hydrolysis percentages of PEtOx (30% and 60%) to reduce ... -
Development of self-assembled poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone) (PEtOx-b-PCL) copolymeric nanostructures in aqueous solution and evaluation of their morphological transitions
Özköse, Umut Uğur; Gülyüz, Sevgi; Öz, Umut Can; Taşdelen, Mehmet Atilla; Alptürk, Onur; Bozkır, Asuman (Budapest Univ Technol & Econ, 2020)Amphiphilic block copolymers are known to self-assemble into various morphologies, including ellipsoids, tubular structures, toroids, vesicles, micellar structures. In this paper, we discuss the synthesis of copolymeric ... -
Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles
Öztürk, Naile; Kara, Aslı; Gülyüz, Sevgi; Özköse, Umut Uğur; Taşdelen, Mehmet Atilla; Bozkır, Asuman (Taylor & Francis Ltd, 2020)Aims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block ... -
PEtOx-DOPE nanoliposomes functionalized with peptide 563 in targeted BikDDA delivery to prostate cancer
Nezir, Ayca Ece; Bolat, Zeynep Büşra; Saka, Ongun Mehmet; Zemheri, Itır Ebru; Gülyüz, Sevgi; Özköse, Umut Uğur; Yilmaz, Özgür; Bozkir, Asuman; Şahin, Fikrettin; Telci, Dilek (TUBITAK, 2024)Background: Nanocarrier-based systems have cultivated significant improvements in prostate cancer therapy. However, the efforts are still limited in clinical applicability, and more research is required for the development ... -
Poly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(epsilon-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activity
Gülyüz, Sevgi; Özköse, Umut Uğur; Khalily, Melek Parlak; Kesici, Mehmet Seçkin; Koçak, Polen; Bolat, Zeynep Büşra; Kara, Aslı; Öztürk, Naile; Özçubukçu, Salih; Bozkır, Asuman; Alptürk, Onur; Telci, Dilek; Şahin, Fikrettin; Vural, İmran; Yılmaz, Özgür (Royal Society of Chemistry, 2021)Here we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer specific targeting ... -
A robust optimization approach for the breast cancer targeted design of PEtOx-b-PLA polymersomes
Öz, Umut Can; Bolat, Zeynep Büşra; Özköse, Umut Uğur; Gülyüz, Sevgi; Küçüktürkmen, Berrin; Khalily, Melek Parlak (Elsevier, 2021)The equipping of nanoparticles with the peptide moiety recognizing a particular receptor, enables cell or tissue specific targeting, therefore the optimization of the targeted nanoparticles is a key factor in the formulation ... -
The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions
Özköse, Umut Uğur; Gülyüz, Sevgi; Parlak Khalily, Melek; Özçubukçu, Salih; Bozkır, Asuman; Taşdelen, Mehmet Atilla (Wiley, 2021)To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these ... -
The Utilization of Poly(2-ethyl-2-oxazoline)-b-Poly(epsilon-caprolactone) Ellipsoidal Particles for Intracellular BIKDDA Delivery to Prostate Cancer
Koçak, Polen; Öz, Umut Can; Bolat, Zeynep Büşra; Özköse, Umut Uğur; Gülyüz, Sevgi; Taşdelen, Mehmet Atilla (Wiley-V C H Verlag Gmbh, 2021)Prostate cancer is the most common cancer, which is about 15-20% among male cancers worldwide. As most common strategies such as radiotherapy, chemotherapy, or surgery alone can be unsuccessful in the treatment of prostate ...
