https://hdl.handle.net/20.500.12960/2 WoS Indexed Publications Collection 2026-04-20T14:31:49Z https://hdl.handle.net/20.500.12960/1821 Automated In-situ Analysis of Tumor-Associated Macrophage Attachment on Antifouling Polymer Brushes Uslan, Volkan; Şeker, Hüseyin; Onaran, İbrahim; Hirtz, Michael; Riehemann, Kristina Tumor-associated macrophages (TAMs) are critical to tumor progression. Quantifying their interactions with biomaterial surfaces is crucial for developing effective cancer therapies. Traditionally, manual cell counting has been used to assess macrophage adhesion, a labor-intensive and subjective process. To address these limitations and enable unbiased analysis, we developed an automated in-situ system to quantify TAM attachment to antifouling polymer brushes. Bland-Altman analysis indicated a high agreement between our automated method and traditional manual cell counting. For M1 macrophages, the mean difference was less than 4 cells, with limits of agreement (LoA) ranging from -70.18% to 80.16%. For M2 macrophages, the mean difference was 25 cells, with LoA ranging from -51.61% to 72.71%. These results were consistent across different experimental conditions, including Unspecific Binding, Specific Antibody, and IgG Control. Our analysis revealed no systematic differences in cell counts and holds significant potential for point-of-care applications, potentially enhancing personalized treatment strategies. 2025-01-01T00:00:00Z https://hdl.handle.net/20.500.12960/1820 Use of unmanned surface vessels for search and rescue in the Arctic Oral, Ferhan The use of unmanned surface vessels (USVs) in the maritime industry has increased rapidly in recent years. At the same time, maritime activity in the Arctic is expanding as diminishing sea ice enables greater access for commercial shipping, offshore energy development, fisheries, and cruise tourism. This growth has heightened the risk of maritime accidents in a region characterized by harsh environmental conditions, vast distances, and limited infrastructure. Existing search and rescue (SAR) capabilities of Arctic states are widely regarded as insufficient to fully address the anticipated increase in maritime traffic, prompting efforts to enhance SAR preparedness. This study examines the potential role of USVs in supporting Arctic SAR operations from operational and legal perspectives, with particular reference to the Northern Sea Route. It addresses two research questions: 'how USVs can support SAR operations in the Arctic in light of existing SAR capabilities and increasing maritime activity', and 'what legal and regulatory constraints may limit their deployment'. A qualitative pilot study was conducted based on semi-structured interviews with domain experts, which were coded and analyzed using content and thematic analysis methods. The findings suggest that USVs can enhance SAR operations as complementary assets, provided that existing legal ambiguities are clarified. 2026-01-01T00:00:00Z https://hdl.handle.net/20.500.12960/1819 A review on recent developments in electrospun polymeric nanofibers for oil–water separation Zembat, Ahmet Alp; Cansoy, C Elif Oil–water separation is an important process used to reduce pollution and recover valuable resources in many industrial applications. Electropun nanofibers with varying chemical composition and dimensions are commonly used to remove pollutants from water. Various nanoadditives, such as clays, metal nanoparticles, and C-based nanoparticles, can also be introduced into the polymeric nanofiber matrix to improve the removal capacity and flux of the prepared membranes. Various studies in the literature have investigated the use of these polymeric nanofibers in the separation of oil–water mixtures and oil–water emissions, and very good separation efficiencies have been supported by experimental studies. This review briefly summarises the recent developments on polymeric nanofibres used in oil–water separation. The reviewed studies showed that wettability, fiber diameter, chemical structure, and composition of the nanofibers are important parameters for the removal of contaminants, and polymeric nanofibers produced by tailoring their chemical composition and dimensions are promising candidates for many oil–water separation applications. 2026-01-01T00:00:00Z https://hdl.handle.net/20.500.12960/1818 Analysis of the effect of wealth taxes in overcoming the Jevons paradox Doğan, Metin Although energy efficiency and renewable energy are crucial tools for combating climate change, their use may inadvertently increase demand for energy and materials by reducing resource costs, a phenomenon known as the Jevons paradox or rebound effect. This study applies KRLS and adaptive LASSO to examine this issue in Turkey for 1985-2022. Two models are constructed with different dependent variables. The results confirm a strong rebound effect for energy efficiency for both models and analytical methods, whereas the rebound effect for renewable energy is only partially validated, and technological development has a limited rebound effect. The KRLS results indicate that wealth taxes reduce energy consumption across all percentiles and fossil fuel consumption per capita in the lower percentiles, while the adaptive LASSO results indicate a negative effect in both models. These findings suggest that wealth taxes may be an effective policy tool to counter the Jevons paradox and promote sustainable energy practices in Turkey. They are also a useful tool for creating a fairer tax system, reducing carbon-intensive production/consumption activities, and generating resources for renewable energy. International cooperation to reintroduce wealth taxes at higher rates will increase their effectiveness. Another key finding is that renewable energy is crucial to achieving zero-carbon targets. In Turkey, however, outdated renewable energy infrastructure and inefficient investments are hindering renewable energy implementation, which should be prioritized by redesigning Turkey's energy and fiscal policies. 2026-01-01T00:00:00Z