Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin
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2021Author
Altınkök, ÇağatayAçık, Gökhan
Karabulut, Hüseyin Rıza Ferhat
Çiftçi, Mustafa
Taşdelen, Mehmet Atilla
Dağ, Aydan
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Açık, G., Taşdelen, M. A., Çiftçi, M., Karabulut, H. R. F., Altınkök, Ç., & Dağ, A. (2021). Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin, p.1-9.Abstract
In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.